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increased glycolysis and decreased mitochondrial respiration through ERK-dependent CPT1A degradation

4 Impaired mitophagy contributes to mitochondrial dysfunction in lupus T cells, leading to necrosis and the release of immunogenic debris that triggers autoantibody production and type I IFN responses

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has received research funding and materials from Pfizer, Calico, Elysium Health and Metro International Biotech and consulting fees from Pfizer, Elysium Health, Cytokinetics and Altimmune, and holds a patent for using NAD + precursors in liver injury

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