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Revisiting glutamate excitotoxicity in amyotrophic lateral sclerosis and age-related neurodegeneration

Geloso et al., 2017

Interestingly, recent studies indicate that in the setting of ATII-induced hypertension, a downregulation of the dihydrofolate reductase was observed, which was accompanied by decreased vascular BH 4 levels and an uncoupled eNOS, 91 implicating a potential role of this salvage pathway in the development of hypertension

These adaptive mechanisms result in glomerular hyperfiltration and increased glomerular capillary pressure and are associated with kidney injury and hypertension in the long run [150]