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Periodic measurement of vitamin B 12 levels for individuals undergoing metformin treatment, especially if they display symptoms like anemia or PN, is integral to this integrated approach aiming to optimize metformins benefits while mitigating potential risks associated with vitamin B 12 deficiency, ensuring comprehensive patient care in the context of diabetes prevention and management [7, 46]

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Total number of axons, axon fiber size, myelin thickness, G-ratio, axon number/mm 2 , diameter of fiber, changes of longitudinal width, and formation of the edema and hematoma were evaluated by transmission electron microscopy

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Eur Spine J 30:2409 Kim HS, Wu PH, Jang IT (2020) Lumbar degenerative disease Part 1: anatomy and pathophysiology of intervertebral discogenic pain and radiofrequency ablation of basivertebral and sinuvertebral nerve treatment for chronic discogenic back pain: a prospective case series and review of literature