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This medicine is also used to manage conditions such as end-stage renal disease (ESRD) on haemodialysis and may be used as supportive therapy for certain fatigue-related conditions, as advised by a doctor

doi: 10.1016/j.diabres.2020.108125 66 IvashkinV.FominV.MoiseevS.BrovkoM.MaslennikovR.UlyaninA.et al

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49 As a core circadian regulator, melatonin stabilizes clock genes (e.g., CLOCK protein), reduces cortisol-mediated immunosuppression, and coordinates rhythmic immune cell activities (e.g., diurnal fluctuations in macrophage phagocytosis), systemically delaying immunosenescence