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110,111 Non-Membrane Disrupting Mechanisms of AMPs Although the electrostatic interaction with tumor cell membrane and further disrupting action is the key of AMPs to kill the tumor cells, certain AMPs are accompanied by other mechanisms, such as inhibiting tumor DNA synthesis, destroying tumor cytoskeleton, inhibiting tumor angiogenesis, destroying tumor mitochondria, inducing tumor cell apoptosis or necrosis, and regulating immunity, as shown in Figure 3

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Response: We thank the commenter for their support of the proposal to adjust Shared Savings Program calculations for SAHS billing activity in advance of issuing initial determinations of shared savings and losses