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Phase II metabolism pathway Most of the metabolites produced by the phase I pathway can be excreted directly or after the phase II metabolism, while the other part is directly excreted

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However, since catecholamine depletion takes some time to develop , reserpine-like drugs must be given several hours to days in advance of tyramine for this interaction to be observable

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The most common side effect at high doses (above 1,500mg IV) is transient mild hypotension or sulfur-related gastrointestinal discomfort

Kent Holtorf, a physician who graduated from UCLA School of Medicine