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P53 phosphorylation at Ser15 was confirmed to enhance the affinity for both FOXO4 and FOXO4-DRI, providing a structural explanation for FOXO4-DRIs preferential engagement with the hyperphosphorylated p53 that characterises senescent cells

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Clinical data across hundreds of participants shows serious adverse events are essentially nonexistent with topical use

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Current Opinion in Investigational Drugs, 7(4), 312-318