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Although the importance of these results should not be overlooked, it should be emphasized that these effects were examined in a microglial cell line and need to be further validated in whole animals

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Lancet 2008

Signs of deficiency The following symptoms may be a sign of B12 deficiency: extreme tiredness lack of energy pins and needles sensation muscle weakness depression and cognitive problems such as impaired memory, understanding and judgement A lack of B12 can lead to a raised level of the amino acid homocysteine in the blood which has been linked to heart disease

doi: 10.1038/s41531-022-00305-y