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ROS can induce mutations in the BRCA1 gene, which is involved in DNA repair, leading to impaired DNA damage response and increased susceptibility to tumorigenesis [100]

The meeting comes at a pivotal time, with FDA scientific reviewers recommending against compounding all seven peptides while HHS leadership has publicly signaled support for expanding access

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Astrocytes, as noted in earlier reports, express most of the enzymes in the kynurenine pathway, except kynurenine-OHase, and can both produce and degrade quinolinic acid (Guillemin et al., 1999)