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GADD45 directly interacts with SIRT1 Although GADD45 overexpression increased SIRT1 protein levels, it did not affect SIRT1 mRNA expression as determined by qRT-PCR (Fig

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Workers who had been exposed to levels of 5 - 36 mg/m 3 , prior to the study, showed an increased frequency of sister chromatid exchange that persisted for at least 24 months after cessation of exposure (Stolley et al., 1984)