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[44] Avoid using retinol cream or serum if you are pregnant

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Statements Author contributions T-BC: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Writing original draft

One possible explanation for the increase in NR2B-containing NMDA receptor expression in HD models is that an extended polyglutamine repeat in htt decreases its binding to PSD95, a postsynaptic density protein involved in NMDA and kainate receptor clustering, leading to increased interaction of PSD95 with the NR2B subunit (Sun et al., 2001

Additionally, both in vitro and in vivo studies demonstrated Tat and methamphetamine mediated synergistic downregulation in the expression of glucose receptors and tight junction proteins and an increase in oxidative stress and BBB permeability (140, 141)