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These impediments can be overcome using one or more of an extensive library of small molecule HGF mimetics which are described herein, some of which are orally active, display profound pro-cognitive/anti-dementia/neuroprotective activity, and are inexpensive to synthesize

The SURMOUNT-5 trial showed that maximum-dose tirzepatide produces about 47% more weight loss than maximum-dose semaglutide, so they are clearly not equivalent at their respective maximums