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an association with systemic diseases such as hemochromatosis, scleroderma, pernicious anemia, and iron-deficiency anemia has also been described.7,8 However, all of these presumed associations were based on individual cases and not on systematic study, and taking into account that a large study conducted in South Africa found pigmented fungiform papillae in 6% of males and 8% of women,2 it is probable that they were merely coincidental

More and more studies have indicated that cell senescence plays a pivotal role in both the onset and progression of AKI, and inhibiting cell senescence can facilitate the recovery of kidney function

Similarly, metabolic disorders can lead to renal damage, which can affect both its structure and function

In: The Status of Differentiation Therapy in Cancer, Vol

To maintain a balance between its functional roles and potential for generation of harmful reactive oxygen species, cellular levels of copper are tightly regulated by a network of proteins responsible for its influx, efflux, transport and storage 1,2