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The dermatitis spread to his forearms, face, and legs, at which point he ceased exposure to the HEFB and his symptoms resolved

Conversely, low levels could indicate malignancies, immune disorders, and corticosteroid use

CW, BW, PX, JX, and XH reviewed and edited the manuscript

A., Bell, N

Future investigations should focus on developing targeted delivery systems for necroptosis inducers, establishing synergistic therapeutic regimens, and optimizing dosage parameters to maximize therapeutic efficacy while minimizing adverse effects, thereby propelling the clinical application of necroptosis therapy (Rucker et al., 2024)