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Areas with lower-selenium soil have been linked to increased Hashimoto thyroiditis in humans (104)

The only alteration we made was the replacement of Met1 by its bioisostere norleucine (Nle) to avoid the notorious oxidation of the Met1 thioether moiety, leading to different molecular weights (M, M+16Da and M+32Da) for a single type of Ub protein, which is detrimental to MS analysis and quantification

During this process ROS is produced

Int J Mol Sci 22:1637 Golding J, Rai D, Gregory S, Ellis G, Emond A, Iles-Caven Y, Hibbeln J, Taylor C (2018) Prenatal mercury exposure and features of autism: a prospective population study