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Ouyang,L., et al.(2022) Overexpressing HPGDS in adipose-derived mesenchymal stem cells reduces inflammatory state and improves wound healing in type 2 diabetic mice

After being fed HFD for a total of 16-weeks (an appropriate rodent model of DIO and comparable to human obesity) and reaching pre-arrival body weights (38 g), mice were randomized into balanced control and treatment cohorts (n=9/cohort), with similar group average body weight and standard deviation

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Goblet cell numbers were transiently reduced, while mucin content per cell increased, likely reflecting a compensatory secretory response

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It stimulates pulsatile growth hormone secretion from somatotropic cells of the anterior pituitary via the GHRH receptor, with downstream IGF-1 induction