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For these populations, the potential for increased oxidative stress from excessive caffeine intake could pose significant health risks

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Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

Mechanistically, Iso reduced ROS and MDA levels, enhanced SOD and CAT activity, and suppressed the NOX4/ROS/NF-B pathway by promoting Nrf2 nuclear translocation (Dai et al., 2018)

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Thus, without the proteolytic activation of certain bacterial exotoxins, diseases such as dysentery or diphtheria would not occur