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Second, because a mortality event could compete with our outcome of interest, we used cause-specific hazard models, in which the death occurring before reaching the primary outcome was treated as a competing risk and censored (26, 27)

In one melanoma study, mice exposed to higher NAC doses experienced greater metastatic activity than those given lower doses, suggesting the effect may be dose-dependent in certain experimental settings.42 Researchers have not established whether these findings apply to humans, but starting with a moderate dose offers a more conservative approach while still aligning with a large portion of the clinical literature

Trivedi et al., 2013)

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