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Acta Pharmacol Sin (2023) 44:14546

Induced pluripotent stem cell (iPSC)-derived human liver organoids (iHLOs) are particularly promising, as they can recapitulate the cellular complexity of the liver, including diverse cell types such as hepatocytes, cholangiocytes, endothelial cells, and occasionally Kupffer cells 11

Their high solubilizing capacity and nanoscale droplet size promote efficient permeation across gastrointestinal barriers, thereby addressing the delivery challenges associated with these volatile oils (125)

446 Studies suggest that for patients who respond poorly to mesalazine, sulfasalazine may provide an alternative that reduces inflammation and ulceration of the intestinal mucosa and possibly improves the local immune response