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Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice

CBD was obtained from a formulation containing 5 mg/ml of CBD (Cayman Chemicals, USA), and was further diluted in saline

Sleep apnea occurs predominantly in middle-aged men and postmenopausal women and is associated with obesity and cardiovascular complications, including hypertension, while narcolepsy and idiopathic hypersomnia are chronic brain disorders with an onset at a young age (5)

(2) Despite the fact that both peptides have distinct mechanisms of action, they have been found to exhibit synergistic effects when used in combination

Clerc I, Moussa DA, Vahlas Z, Tardito S, Oburoglu L, Hope TJ, Sitbon M, Dardalhon V, Mongellaz C, Taylor N