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The protective effects of L -carnitine on myocardial ischaemia-reperfusion injury in patients with rheumatic valvular heart disease undergoing CPB surgery are associated with the suppression of NF-kappaB pathway and the activation of Nrf2 pathway

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For example, Nadatani in 2016 reported that caspase-1 can induce pyroptosis, a unique form of programmed cell death, through the conversion of pro-IL1 and pro-IL18 in their active forms, which promotes further inflammation

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The endotoxin hypothesis of Alzheimers disease

10.1016/j.freeradbiomed.2015.04.036 37 DjouadiF.AubeyF.SchlemmerD.BastinJ