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UA and stroke Several observational studies have assessed the relationship between UA levels and neurological outcomes after acute stroke

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ASP, owing to its high solubility, biocompatibility, biodegradability, abundant hydroxyl groups, and modifiability, is an ideal candidate for constructing amphiphilic polymeric micelles with therapeutic potential (226, 227)

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Mechanistically, mTORC1 promotes the proteasome-mediated destabilization of CREB2 to suppress SIRT4 (a mitochondria-localized member of the sirtuin family), which inhibits GDH, thereby enhancing GDH enzymatic activity