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Selank balances neurotransmitters such as serotonin, dopamine, and GABA, promoting calm and emotional stability

Furthermore, among the possible molecular targets of LAs action identified through in silico studies, endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and 5-lipoxygenase were highlighted, among other proteins ( Based on this, the objectives of this study were to confirm these potential interaction targets of LA, highlighting its mechanism of action in vitro , and to evaluate LAs role in the oxidative stress imbalance for the prevention of tracheal hyperresponsiveness in asthmatic Wistar rats

RBC lysis (BioLegend) was performed and CRTH2 + cells were then isolated using the CRTH2 MicroBead Kit (Myltenyi Biotec) according to the manufacturers instructions

[175] [176] These vitamins act as coenzymes and are particularly relevant for ocular well-being

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A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound according to formula (IV): wherein: R 1 is selected from the group consisting of aryl, C 1-6 alkyl-aryl, and C 3-10 carbocycle, wherein the aryl, C 1-6 alkyl-aryl, and C 3-10 carbocycle may be optionally substituted with an atom or a group selected from the group consisting of halo, deuterium, C 1-6 alkyl, CF 3 , and combinations thereof