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In addition, a significant increase was noted in GH-deficient children during treatment with rhGH, suggesting that GH and/or IGF-1 affect acid-base hemostasis

however, they also cause side effects, including infection and immunosuppression

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doi: 10.1177/00037028241236501 106 Hernndez-MarianoJ..Baltazar-ReyesM

Methods In this study, we recruited a cohort comprising children with obesity (body mass index over two z -scores above the age/sex-adjusted mean of the Spanish reference population, age range: 612 years), born to parents with obesity ( N = 18) or without obesity ( N = 41), as well as matched healthy controls ( N = 26)