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In conclusion, microbial BAs are not passive metabolites but active modulators of anti-tumor immunity

When superoxide radical and NO are both produced in large amount, they react together and give rise to a much more reactive free radical called the peroxynitrite anion (ONOO-) which cause DNA fragmentation and lipid peroxidation (Carr 2000)

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Grosso G, Micek A, Marventano S, et al

Niu F, Dong J, Xu X, Zhang B, Liu B (2019) Mitochondrial division inhibitor 1 prevents early-stage induction of mitophagy and accelerated cell death in a rat model of moderate controlled cortical impact brain injury

doi: 10.1096/fasebj.31.1_supplement.804.3 77 MengJ.YuH.MaJ.WangJ.BanerjeeS.CharboneauR.et al