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External stimuli responsive and non-cleavable internal stimuli responsive conjugations are beyond the scope of this review

These compounds work by: Inhibiting thyroid-stimulating hormone (TSH) activity Blocking the binding of antibodies to TSH receptors Reducing the peripheral conversion of thyroxine (T4) to triiodothyronine (T3, the active form of thyroid hormone) Research has shown that bugleweed can effectively decrease thyroid hormone levels and alleviate symptoms associated with hyperthyroidism

& Whitehead, I

64 KuangH.TangZ.ZhangC.WangZ.LiW.YangC.et al (2017)

In addition, SA can induce epigenetic changes, as its accumulation can modify the structure of chromatin

Pseudomonas exotoxin A (PE) is an extremely active monomelic protein (molecular weight 66 kD), secreted by Pseudomonas aeruginosa, which inhibits protein synthesis in eukaryotic cells through the inactivation of elongation factor 2 (EF-2) by catalyzing its ADP-ribosylation (catalyzing the transfer of the ADP ribosyl moiety of oxidized NAD onto EF-2)