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Anti Cancer Agents Med Chem 17(1):420 Dauchy RT, Xiang S, Mao L et al (2014) Circadian and melatonin disruption by exposure to light at night drives intrinsic resistance to tamoxifen therapy in breast cancer

260,261 These changes amplify inflammation triggered by environmental insults such as cigarette smoke, while accelerated cellular aging (e.g., telomere shortening in alveolar cells) further drives oxidative stress and apoptosis

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doi: 10.1038/s41467-024-49186-0 60 KapoorMMartel-PelletierJLajeunesseDPelletierJPFahmiH

The upregulation of Nrf2 expression appears to exert an anti-inflammatory effect on RA

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