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In an animal study, neonatal SOD1 G93A mice receiving injection of a single-stranded AAV9 vector encoding an artificial mRNA against human SOD1 in the cerebral lateral ventricles showed improvements in multiple parameters including survival, number of MNs, the extent of neuroinflammation, diameter of ventral root axons and pulmonary function [137]

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Clin Ter (2016) 167:e11722

Inhibition of the ROS signaling pathway severely delays or impairs plant hormesis effect, and decreases plants abiotic stress tolerane ( Ascorbate may induce a biphasic response in plants under abiotic stresses