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Cultivating a Safety -First Culture Within Research Organizations A safety -first culture is cultivated when every member of a research organization from clinicians to administrative personnelembraces the core principle that patient safety is paramount

doi: 10.2337/db08-0593 [DOI] [PMC free article] [PubMed] [Google Scholar] 30.Pittas AG, Dawson-Hughes B, Sheehan P, et al

Baker FC, de Zambotti M, Colrain IM, Bei B

Clinically Important Drug Interactions with PPIs Reduced absorption due to gastric pH Azoles: Ketoconazole, Itraconazole, Posaconazole (oral) Antiretrovirals: Atazanavir , Rilpivirine Oral anticancer drugs (pH-dependent) Erlotinib, Gefitinib, Dasatinib, Nilotinib Iron salts, Calcium carbonate Mycophenolate mofetil Increased exposure / toxicity High-dose Methotrexate delayed clearance & toxicity Warfarin INR (monitor closely) Phenytoin, Diazepam Long-term safety concerns Hypomagnesemia (higher risk with diuretics) Clostridioides difficile infection Fracture risk with prolonged use Clinical Pearl Avoid unnecessary PPIs in patients receiving pH-dependent oral anticancer therapies

Designed to deliver results without the trade off

S., Sanchez J