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The American Academy of Family Physicians reports that about 50 percent of adults have low magnesium levels (2022)

2013, Sonnewald et al

Excessive iron loading increases the expression of M1-associated inflammatory mediators, including IL-6, TNF-, and IL-1, while suppressing M2 markers such as transglutaminase 2 (TGM2), so efficiently guiding polarization toward the pro-inflammatory M1 phenotype (97)

2013 Oct;38(11):2220-30

DMs intimate link with oxidative stress, makes NS therapy relevant since it is a potent antioxidant that energizes the cells endogenous arsenal of antioxidant enzymes