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Perfusate analyses 5 mL of perfusate were collected at the beginning (T0) and at the end (T1) of perfusion from the perfusion fluid in the organ container and centrifuged at 2500 rpm for 15 min to remove cellular debris

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Unfortunately, so far no detailed toxicity studies have been carried out and thus, at the moment the clinical use of such extracts cannot be recommended (Moriasi et al

W., Zhu, Z

[5154] Moreover, in a process called enterohepatic recirculation, gut microflora also have the ability to remove some conjugation moieties, such as glucuronosyl side chains, converting the xenobiotic to its original form, and allowing it to reenter circulation, leading to an increased toxic load

Additionally, apigenin exhibits antioxidant activity by increasing superoxide dismutase (SOD), glutathione peroxidase (GPx), and reduced malondialdehyde (MDA) levels in the injured brain (T