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[19] Synaptic scaling is a homeostatic mechanism that helps neurons stabilize their activity by adjusting the strength of all their synapses up or down in response to prolonged changes in input

It is highly likely that the various phases of MS thus represent a continuum of the same disease, where autoimmune inflammation is most prominent early, gradually wanes with age, thus unmasking a progressive underlay of chronic cytodegenerative processes that are present from disease inception