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Dietary intake is significant, particularly in those who follow vegan or vegetarian diets, as B12 is primarily found in animal products

Following a catalytic turnover, the product glutamate has a relatively low affinity for the enzyme and no longer interacts with Tyr182 and Glu314

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In terms of alterations in the activity of ERs, an overexpression of ER and a downregulation of ER have been observed in endometriosis [34]

Titulaer JM, Wirtz PW, Wintzen AR, et al

Milea SA, Lazar NN, Simionov IA, et al