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Weaver et al., 2009)

However, it did not significantly improve treatment success, painful defecation, and abdominal pain ( Radiotherapy and chemotherapy are commonly used therapeutic approaches for cancer patients

Competing interests The authors declare that there were not any commercial or financial relationships that could be construed as a potential conflict of interest

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To address this issue, researchers must focus on optimizing methods that account for stemness stability through modulating signaling pathways, such as Notch and Wnt/-catenin [135], or using small molecules to enhance SCs self-renewal capabilities, including glutathione, melatonin, and ascorbic acid (ASA) [136]