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International Journal of Radiation Oncology, Biology, Physics 69:S686, 2007

Petitjean M, Garca-Zubiri IX, Isasi JR

Additionally, pattern recognition receptors like TLR2 and TLR4 on microglia can be chronically stimulated or desensitized by repetitive exposure to microbial MAMPs translocating from the gut, potentially affecting how microglia respond to misfolded proteins (either by over-reacting and causing bystander damage, or by entering a tolerant state that might impair clearance of aggregates) [71, 119]