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Less than a one percent of the NIHs annual budget is dedicated to migraine research $14 million, some 36 cents per sufferer

Org Biomol Chem 7:15471553 Humphrey JM, Chamberlin AR (1997) Chemical synthesis of natural product peptides: coupling methods for the incorporation of noncoded amino acids into peptides

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In double-blind, placebo-controlled trials, daily application of GHK-Cu cream at 3% concentration for 12 weeks produced a 70% increase in skin collagen thickness as measured by ultrasound imaging, a 40% increase in skin elasticity, and visible reduction in fine lines and wrinkles

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The following adverse event rates were reported at any time following initial injection and prior to reinjection or study exit (median duration of 44 weeks of exposure): UTIs (49%), urinary retention (17%), constipation (4%), muscular weakness (4%), dysuria (4%), fall (3%), gait disturbance (3%), and muscle spasm (2%)