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Cancer Res 49: 64496465 Venneti S, Dunphy MP, Zhang H, Pitter KL, Zanzonico P, Campos C, Carlin SD, La Rocca G, Lyashchenko S, Ploessl K, Rohle D, Omuro AM, Cross JR, Brennan CW, Weber WA, Holland EC, Mellinghoff IK, Kung HF, Lewis JS, Thompson CB (2015) Glutaminebased PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo

Metabolomics usually only reports the confidence of a chemical assignment to a peak and seldom reports analytical verification of a potential biomarker

After the pivotal clinical trial, the PPK and ER models have been frequently applied for dose confirmation and benefit/risk assessment, along with clinical efficacy and safety data

Whilst one meta-analysis of 24 RCTs found a decrease in the pro-inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6), 15 the other (based on 28 studies) found a decrease in interleukin-8 (IL-8) when pooling all data and a decrease in IL-6 in a subset of studies using a dose of 1200 mg NAC per day or less, but no difference in CRP

PMID: 27423583

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