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PubMed Mihovilovic, K., Sever, M., Zoricic, I., et al

Acknowledgements We acknowledge co-funding from the Fondazione per la Ricerca Biomedica Saverio e Isabella Cianciola and from Next Generation EU, in the context of the National Recovery and Resilience Plan, Investment PE8 Project Age-It: Ageing Well in an Ageing Society

This would support either camp of thought around whether PD pathology is driven by a proteinopathy (toxic accrual of S aggregates gain of function) or a proteinopenia (loss of S native function)

For example, Liu and collaborators observed similar effects to those described in HCC, but in pancreatic cancer cells (Liu et al., 2018 [19])

This approval represents the first FDA-approved drug specifically targeting mitochondrial function, establishing regulatory precedent for the mitochondrial dysfunction pathway in aging and neurodegeneration

Bischof, C