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Treg cells in vWAT have a unique transcriptome compared to Tregs in other tissue, with overexpression of transcription factors, such as peroxisome proliferator-activated receptor (PPAR), chemokines, cytokines, and their receptors

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Preeminent among these are the sirtuin family of deacetylases with fundamental regulatory roles in metabolism, healthspan and longevity 37

Nutrition: Maintain adequate dietary fats for steroid-hormone synthesis and sufficient protein and micronutrients (zinc, vitamin D, magnesium)