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10.1152/physiolgenomics.00070.2018 90

VITAMIN C Also known as ascorbic acid, is a powerful antioxidant that helps prevent free radical damage

Exercise-induced oxidative stress in humans: cause and consequences

They also observed reduced translocation of p65 to nucleus thus reducing NF- mediated activation of various pro-inflammatory genes including TNF-, IL-17, IL-6, and IL-1 within arthritic joint microenvironment where they can influence osteoclast differentiation thus promoting joint destruction

151 In summary, SIRT1 precisely regulates pyroptosis at initiation, execution, and downstream inflammatory signaling

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