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Growth hormone is part of this system as well, exerting a nuanced but crucially important effect in maintaining control of reproductive hormones

E3 ligases have the capacity to selectively recognize substrates, determining the specificity of ubiquitination

TMEM206 plays a role in mediating acid-induced cell death as well as cell proliferation and migration, and its regulation is dependent on p53 through a p21-dependent mechanism (346)