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doi: 10.1016/S0092-8674(00)80611-X

Low levels of glutathione have been linked to a wide variety of diseases including cancer, diabetes, cardiovascular disease, neurodegenerative disorders, autoimmunity and accelerated aging

38 Moreover, p53 loss in our cellular model leads to the upregulation of xCT, promoting cystine import and GSH synthesis to shield cells from ferroptotic cell death

It may possibly reflect differences in the occupancy of the hydrophobic pocket in VP1, or at another site affecting stability, since the ternary complexes of PV3-SC8 GPP3+GSH and PV3-SC8 pleconaril+GSH demonstrate that the bound factors could act additively or synergistically

[PubMed] [Google Scholar] 21.Hoehle S.I., Pfeiffer E., Metzler M