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Infusion related symptoms often calm down as soon as the infusion stops or slows

In some embodiments, the invention encompasses cations of Formula I, wherein: R 1 is C 1-4 alkyl

Some people notice changes in comfort or mobility over several weeks, while deeper tissue remodeling can take longer

Patients who had significant swelling often report visible reduction

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This short-term flare is usually managed with relative rest, ice if advised, and simple pain relief