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Description

ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension

N was joined to the C-terminus of the elastin-like polypeptide (ELP) via a flexible linker ELP-N (construct 5), and mutant C* was fused to the N-terminus of various sample target proteins C*-POI (construct 3, 6-10)

No formal clinical trial has studied this specific combination

[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Soubeyrand E., Kelly M., Keene S.A., Bernert A.C., Latimer S., Johnson T.S., Elowsky C., Colquhoun T.A., Block A.K., Basset G.J