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In a differential alkylation approach, peptides containing Cys (either chemically alkylated or initially oxidized) are used to estimate Cys oxidation levels, while peptides not containing Cys are used for measurement of protein expression

White AJ, Chen J, McCullough LE, Xu X, Cho YH, Teitelbaum SL, Neugut AI, Terry MB, Hibshoosh H, Santella RM, Gammon MD

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MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights

Despite the fact that many synthetic compounds with antioxidant activity have been developed and applied as therapies for oxidative stress-related diseases, their effectiveness has been disappointing [16] (Figure 7)

doi: 10.1089/jmf.2017.0139 56 LakshimarayenV.MuthanaM