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The recent success of LNP-mRNA vaccines and RNA interference therapies underscores this potential [54]

Loss of mitochondrial structure and function leading to impaired GSIS may be also caused by mutations of the nuclear-encoded genes

Activating the GSH system alleviates the progression of the myocardial injury by blocking the ferroptosis pathway and oxidative stress, which provides a promising therapeutic strategy for cardiac diseases

Parsons CL, Greenberger M, Gabal L et al: The role of urinary potassium in the pathogenesis and diagnosis of interstitial cystitis

Dually phosphorylated PPPSPxS motifs (designated PPPpSPxpS) act synergistically and interchangeably to inhibit GSK3 in Wnt-stimulated cells 33 , however only the phosphorylation at P + 4 is essential for Wnt signal transduction while that at P + 7 is merely contributory 25