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Standardization of Senescence Biomarkers: A major challenge in both the development and application of senescence-targeting therapies is the identification of reliable biomarkers that can accurately assess the presence of senescent cells and their effects.256 Current biomarkers for senescence, such as p16^INK4a, -galactosidase activity, and SASP factors, are useful in research settings, but their clinical applicability remains limited

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Failure to treat the root cause means deficiency is likely to recur

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However, in some cancers, such as gliomas [292] and neuroblastomas [293], SLC3A2 is an important transporter for polyamine uptake

Evidence gap There is no modern, large-sample, FDA-recognized RCT establishing DSIP's efficacy in any indication