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1000 g For a 4 ml ampoule

Most reports describe first changes at weeks 4 to 6, with peak effect at 8 to 12 weeks

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Some historical or research protocols have used much higher doses (e.g., 250 mg/kg as a single IV bolus in diagnostic growth-hormone testing), but such regimens are uncommon outside controlled studies.Dose escalation should proceed cautiously, with monitoring of vital signs, electrolytes, and-if relevant-ammonia levels

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