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Primary Hereditary Haemochromatosis and Pregnancy

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To limit invasion of pathogens, a balance of ROS-scavenging and ROS-producing pathways is necessary for proper defense mechanism

In contrast, for those who developed the disease earlier than age 50, further data analysis disclosed there was greater genetic concordance in the MZ twins

The same LASSS treatment also conferred nitration resistance with a greater effect for Y198 than Y250, indicating a novel mechanism independent of an anti-oxidative function of LASSS

Overall, ROS-based cascades function in a degraded manner, leading to the development of severe diseases