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In particular, colonization reestablishes physiological colonic paracellular permeability, maturation of colonic barrier structure, and reduces systemic microbial antigen exposure (190)

Similar to the periplasm, the GSH:GSSG ratio in the ER is lower (3:1 to 1:1) compared to the cytosol (100:1), resulting in a more oxidizing environment (Hwang et al., 1992)

Hypoxia stabilizes HIF-1, enabling its nuclear translocation and activation of hypoxia-responsive genes, including those involved in autophagy

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8EI), suggesting that basal and/or secretory progenitor populations may be more vulnerable to NUPR1 inhibition than ciliated cells

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